Protein-coding gene in the species Homo sapiens
OR8K3 |
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Identifiers |
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Aliases | OR8K3, OR11-181, olfactory receptor family 8 subfamily K member 3 (gene/pseudogene) |
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External IDs | MGI: 3030888; HomoloGene: 133882; GeneCards: OR8K3; OMA:OR8K3 - orthologs |
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Gene location (Human) |
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![Chromosome 11 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_human_chromosome_11.svg/300px-Ideogram_human_chromosome_11.svg.png) | Chr. | Chromosome 11 (human)[1] |
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| Band | 11q12.1 | Start | 56,315,144 bp[1] |
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End | 56,320,639 bp[1] |
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Gene location (Mouse) |
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![Chromosome 2 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/260px-Ideogram_house_mouse_chromosome_2.svg.png) | Chr. | Chromosome 2 (mouse)[2] |
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| Band | 2|2 D | Start | 86,162,479 bp[2] |
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End | 86,165,777 bp[2] |
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Gene ontology |
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Molecular function | - G protein-coupled receptor activity
- odorant binding
- olfactory receptor activity
- signal transducer activity
| Cellular component | - integral component of membrane
- plasma membrane
- membrane
| Biological process | - sensory perception of smell
- signal transduction
- response to stimulus
- detection of chemical stimulus involved in sensory perception of smell
- G protein-coupled receptor signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | |
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ENSG00000262755 ENSG00000280314 |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 11: 56.32 – 56.32 Mb | Chr 2: 86.16 – 86.17 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Olfactory receptor, family 8, subfamily K, member 3, also known as OR8K3, is a protein which in humans is encoded by the OR8K3 gene.[5]
Function
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]
References
- ^ a b c ENSG00000280314 GRCh38: Ensembl release 89: ENSG00000262755, ENSG00000280314 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075190 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR8K3 olfactory receptor, family 8, subfamily K, member 3".; This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Further reading
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
Class I (fish-like receptors) | Family 51 | |
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Family 52 | |
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Family 56 | |
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Class II (tetrapod specific receptors) | Family 1 | |
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Family 2 | |
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Family 3 | |
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Family 4 | |
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Family 5 | |
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Family 6 | |
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Family 7 | |
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Family 8 | |
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Family 9 | |
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Family 10 | |
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Family 11 | |
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Family 12 | |
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Family 13 | |
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