OR2AE1

Protein-coding gene in the species Homo sapiens
OR2AE1
Identifiers
AliasesOR2AE1, OR2AE2, olfactory receptor family 2 subfamily AE member 1
External IDsHomoloGene: 128272; GeneCards: OR2AE1; OMA:OR2AE1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for OR2AE1
Genomic location for OR2AE1
Band7q22.1Start99,876,062 bp[1]
End99,877,033 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right coronary artery

  • skeletal muscle tissue

  • duodenum

  • gastric mucosa

  • muscle of leg

  • triceps surae

  • gastrocnemius muscle

  • islet of Langerhans

  • prefrontal cortex

  • anterior pituitary
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81392

n/a

Ensembl

ENSG00000244623

n/a

UniProt

Q8NHA4

n/a

RefSeq (mRNA)

NM_001005276

n/a

RefSeq (protein)

NP_001005276

n/a

Location (UCSC)Chr 7: 99.88 – 99.88 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Olfactory receptor 2AE1 is a protein that in humans is encoded by the OR2AE1 gene.[3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000244623 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: OR2AE1 olfactory receptor, family 2, subfamily AE, member 1".

Further reading

  • Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Thompson EE, Kuttab-Boulos H, Yang L, et al. (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster". Pharmacogenomics J. 6 (2): 105–14. doi:10.1038/sj.tpj.6500347. PMID 16314882. S2CID 10102745.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
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