Protein-coding gene in the species Homo sapiens
| OR2L13 |
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| Identifiers |
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| Aliases | OR2L13, OR2L14, olfactory receptor family 2 subfamily L member 13 |
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| External IDs | MGI: 3030000; HomoloGene: 88350; GeneCards: OR2L13; OMA:OR2L13 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 1 (human)[1] |
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| | Band | 1q44 | Start | 248,095,184 bp[1] |
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| End | 248,101,103 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 16 (mouse)[2] |
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| | Band | 16|16 A3 | Start | 19,302,444 bp[2] |
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| End | 19,308,632 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - prefrontal cortex
- C1 segment
- Brodmann area 9
- hypothalamus
- endothelial cell
- right frontal lobe
- anterior cingulate cortex
- substantia nigra
- primary visual cortex
- putamen
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| | | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - G protein-coupled receptor activity
- protein binding
- olfactory receptor activity
- signal transducer activity
| | Cellular component | - integral component of membrane
- plasma membrane
- membrane
| | Biological process | - sensory perception of smell
- signal transduction
- response to stimulus
- detection of chemical stimulus involved in sensory perception of smell
- G protein-coupled receptor signaling pathway
- biological process
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_001304535
NM_175911
NM_001395936 |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 1: 248.1 – 248.1 Mb | Chr 16: 19.3 – 19.31 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Olfactory receptor 2L13 is a protein that in humans is encoded by the OR2L13 gene.[5]
Function
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [5] OR2L13 was recently implicated in regulating platelet reactivity and growth of abdominal aortic aneurysms [6]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000196071 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056822 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR2L13 olfactory receptor, family 2, subfamily L, member 13".
- ^ Morrell CN, Mix D, Aggarwal A, Bhandari R, Godwin M, Owens P, et al. (May 2022). "Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms". The Journal of Clinical Investigation. 132 (9). doi:10.1172/JCI152373. PMC 9057618. PMID 35324479.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
