OR2A12

Protein-coding gene in the species Homo sapiens
OR2A12
Identifiers
AliasesOR2A12, OR2A12P, OR2A16P, olfactory receptor family 2 subfamily A member 12
External IDsMGI: 3030280; HomoloGene: 17179; GeneCards: OR2A12; OMA:OR2A12 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for OR2A12
Genomic location for OR2A12
Band7q35Start144,086,278 bp[1]
End144,098,953 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for OR2A12
Genomic location for OR2A12
Band6|6 B2.1Start42,898,311 bp[2]
End42,908,075 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • signal transducer activity
  • olfactory receptor activity
  • G protein-coupled receptor activity
Cellular component
  • plasma membrane
  • membrane
  • integral component of membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

346525

258292

Ensembl

ENSG00000221858
ENSG00000284949

ENSMUSG00000073111

UniProt

Q8NGT7

Q8VEV0

RefSeq (mRNA)

NM_001004135

NM_146295

RefSeq (protein)

NP_001004135

NP_666407

Location (UCSC)Chr 7: 144.09 – 144.1 MbChr 6: 42.9 – 42.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2A12 is a protein that in humans is encoded by the OR2A12 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c ENSG00000284949 GRCh38: Ensembl release 89: ENSG00000221858, ENSG00000284949 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073111 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR2A12 olfactory receptor, family 2, subfamily A, member 12".

Further reading

  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.145.6233. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Gilad Y, Lancet D (2003). "Population differences in the human functional olfactory repertoire". Mol. Biol. Evol. 20 (3): 307–14. doi:10.1093/molbev/msg013. PMID 12644552.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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