OR2T4

Protein-coding gene in the species Homo sapiens
OR2T4
Identifiers
AliasesOR2T4, OR1-60, OR2T4Q, olfactory receptor family 2 subfamily T member 4
External IDsMGI: 3030058; HomoloGene: 133015; GeneCards: OR2T4; OMA:OR2T4 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for OR2T4
Genomic location for OR2T4
Band1q44Start248,361,665 bp[1]
End248,362,627 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for OR2T4
Genomic location for OR2T4
Band11|11 B1.3Start58,456,682 bp[2]
End58,461,379 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • prefrontal cortex

  • Brodmann area 9

  • primary visual cortex

  • substantia nigra
Top expressed in
  • esophagus

  • conceptus

  • placenta
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

127074

258198

Ensembl

ENSG00000196944
ENSG00000275617
ENSG00000274870

ENSMUSG00000059279

UniProt

Q8NH00

M9MMJ7

RefSeq (mRNA)

NM_001004696

NM_207695

RefSeq (protein)

NP_001004696

NP_997578

Location (UCSC)Chr 1: 248.36 – 248.36 MbChr 11: 58.46 – 58.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2T4 is a protein that in humans is encoded by the OR2T4 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

OR2T4 has known odorant ligands, many of which have a "floral", "soapy", or "waxy" character, similar to lily of the valley:

See also

References

  1. ^ a b c ENSG00000275617, ENSG00000274870 GRCh38: Ensembl release 89: ENSG00000196944, ENSG00000275617, ENSG00000274870 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059279 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR2T4 olfactory receptor, family 2, subfamily T, member 4".
  6. ^ Yasi EA, Eisen SL, Wang H, Sugianto W, Minniefield AR, Hoover KA, Branham PJ, Peralta-Yahya P (2019). "Rapid Deorphanization of Human Olfactory Receptors in Yeast". Biochemistry. 58 (16): 2160–2166. doi:10.1021/acs.biochem.8b01208. PMC 6482435. PMID 30977365.

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
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Family 56
Class II
(tetrapod specific receptors)
Family 1
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Family 4
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