POLD1

Identifikatori

Alijasi

POLD1

Spoljašnji ID

OMIM: 174761 MGI: 97741 HomoloGene: 2014 GeneCards: POLD1

Genska lokacija (miš)

Hr.	Chromosome 7 (mouse)^[1]

Band	7 B3\|7 28.83 cM	Start	44,182,170 bp^[1]
Band	7 B3\|7 28.83 cM	Kraj	44,198,273 bp^[1]

Obrazac RNK izražavanja

More reference expression data

Genska ontologija
Molecular function	• transferase activity • nucleotide binding • DNA binding • 4 iron, 4 sulfur cluster binding • nucleotidyltransferase activity • iron-sulfur cluster binding • chromatin binding • metal ion binding • damaged DNA binding • GO:0001948, GO:0016582 везивање за протеине плазме • 3'-5' exonuclease activity • 3'-5'-exodeoxyribonuclease activity • nucleic acid binding • DNA-directed DNA polymerase activity • nuclease activity • exonuclease activity • hydrolase activity
Cellular component	• мембрана • Нуклеоплазма • aggresome • nucleotide-excision repair complex • једро • delta DNA polymerase complex • цитосол
Biological process	• nucleotide-excision repair, DNA gap filling • DNA synthesis involved in DNA repair • cellular response to UV • репликација ДНК • fatty acid homeostasis • DNA mismatch repair • translesion synthesis • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • telomere maintenance • response to UV • nucleotide-excision repair, DNA incision, 5'-to lesion • DNA ligation • GO:0100026 поправка ДНК • cellular response to DNA damage stimulus • base-excision repair, gap-filling • Korektura • telomere maintenance via semi-conservative replication • DNA-dependent DNA replication
Sources:Amigo / QuickGO

Ortolozi

Vrste

Čovek

Miš

Entrez


5424


18971

Ensembl


ENSG00000062822


ENSMUSG00000038644

UniProt


P28340


P52431

RefSeq (mRNA)


NM_001256849 NM_001308632 NM_002691


NM_011131

RefSeq (protein)


NP_001243778 NP_001295561 NP_002682


NP_035261

Location (UCSC)

n/a

Chr 7: 44.18 – 44.2 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Katalitička podjedinica DNK polimeraze delta je enzim koji je kod ljudi kodiran POLD1 genom.^[4]^[5] Ona je komponenta kompleksa DNK polimeraza delta.

POLD1, zajedno sa enzimom POLE, je asocirana sa višestrukim adenomom.^[6]

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000038644 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chung DW, Zhang JA, Tan CK, Davie EW, So AG, Downey KM (1992). „Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene”. Proc Natl Acad Sci U S A. 88 (24): 11197—201. PMC 53101 . PMID 1722322. doi:10.1073/pnas.88.24.11197.
^ „Entrez Gene: POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa”.
^ Palles C, Cazier JB et al. Nature Genetics 2013. Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.

Literatura

Kemper RR, Ahn ER, Zhang P, et al. (1992). „Human DNA polymerase delta gene maps to region 19q13.3-q13.4 by in situ hybridization.”. Genomics. 14 (1): 205—6. PMID 1427831. doi:10.1016/S0888-7543(05)80311-8.
Yang CL, Chang LS, Zhang P, et al. (1992). „Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase delta.”. Nucleic Acids Res. 20 (4): 735—45. PMC 312012 . PMID 1542570. doi:10.1093/nar/20.4.735.
Popanda O, Thielmann HW (1992). „The function of DNA polymerases in DNA repair synthesis of ultraviolet-irradiated human fibroblasts.”. Biochim. Biophys. Acta. 1129 (2): 155—60. PMID 1730053. doi:10.1016/0167-4781(92)90480-N.
Lee MY, Toomey NL (1987). „Human placental DNA polymerase delta: identification of a 170-kilodalton polypeptide by activity staining and immunoblotting.”. Biochemistry. 26 (4): 1076—85. PMID 2436659. doi:10.1021/bi00378a014.
Dresler SL, Gowans BJ, Robinson-Hill RM, Hunting DJ (1989). „Involvement of DNA polymerase delta in DNA repair synthesis in human fibroblasts at late times after ultraviolet irradiation.”. Biochemistry. 27 (17): 6379—83. PMID 3146346. doi:10.1021/bi00417a028.
Nishida C, Reinhard P, Linn S (1988). „DNA repair synthesis in human fibroblasts requires DNA polymerase delta.”. J. Biol. Chem. 263 (1): 501—10. PMID 3335506.
Hindges R, Hübscher U (1997). „Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2).”. Genomics. 44 (1): 45—51. PMID 9286699. doi:10.1006/geno.1997.4838.
Wu SM, Zhang P, Zeng XR, et al. (1998). „Characterization of the p125 subunit of human DNA polymerase delta and its deletion mutants. Interaction with cyclin-dependent kinase-cyclins.”. J. Biol. Chem. 273 (16): 9561—9. PMID 9545286. doi:10.1074/jbc.273.16.9561.
Coll JM, Hickey RJ, Cronkey EA, et al. (1998). „Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome.”. Oncol. Res. 9 (11-12): 629—39. PMID 9563011.
Fox G, Popanda O, Thielmann HW (1998). „Evidence for reduced copying fidelity of DNA polymerases alpha, delta, and epsilon from Novikoff hepatoma cells.”. J. Cancer Res. Clin. Oncol. 123 (11-12): 659—68. PMID 9620226. doi:10.1007/s004320050121.
Kim ST, Lim DS, Canman CE, Kastan MB (2000). „Substrate specificities and identification of putative substrates of ATM kinase family members.”. J. Biol. Chem. 274 (53): 37538—43. PMID 10608806. doi:10.1074/jbc.274.53.37538.
Mo J, Liu L, Leon A, et al. (2000). „Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA.”. Biochemistry. 39 (24): 7245—54. PMID 10852724. doi:10.1021/bi0000871.
Budworth H, Dianova II, Podust VN, Dianov GL (2002). „Repair of clustered DNA lesions. Sequence-specific inhibition of long-patch base excision repair be 8-oxoguanine.”. J. Biol. Chem. 277 (24): 21300—5. PMID 11923315. doi:10.1074/jbc.M201918200.
Ohta S, Shiomi Y, Sugimoto K, et al. (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200.
Smith RW, Nasheuer HP (2002). „Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180.”. FEBS Lett. 527 (1-3): 143—6. PMID 12220650. doi:10.1016/S0014-5793(02)03197-6.
Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M (2002). „Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication.”. Biochim. Biophys. Acta. 1578 (1-3): 59—72. PMID 12393188. doi:10.1016/S0167-4781(02)00497-9.
Xie B, Mazloum N, Liu L, et al. (2002). „Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme.”. Biochemistry. 41 (44): 13133—42. PMID 12403614. doi:10.1021/bi0262707.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Shevelev IV, Ramadan K, Hübscher U (2004). „The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy.”. ScientificWorldJournal. 2: 275—81. PMID 12806015. doi:10.1100/tsw.2002.99.

DNK replikacija (Prokariotska, Eukariotska)

Separacija
i inicijacija

Prokariotska (inicijacija)	Prereplikacioni kompleks Cdc6 Helikaza (dnaA, dnaB, T7) · Primaza (dnaG)
Eukariotska (priprema u G1 fazi)	Prereplikacioni kompleks: Kompleks prepoznavanja mesta početka (ORC1, ORC2, ORC3, ORC4, ORC5, ORC6) · Održavanje minihromozoma (MCM2 · MCM3 · MCM4 · MCM5 · MCM6 · MCM7) · CDC6 Faktor licenciranja Autonomna replikaciona sekvenca Protein jednolančanog vezivanja (SSBP1, SSBP2, SSBP3, SSBP4) RNaza H (RNASEH1, RNASEH2A) Helikaza: HFM1 Primaza: PRIM1 · PRIM2
Oba	Početak replikacije/Ori/Replikon Replikaciona viljuška (zaostajući i vodeći lanci) · Okazakijev fragment · Prajmer

Replikacija

Prokariotska (elongacija)	DNK polimeraza III holoenzim (dnaC, dnaE, dnaH, dnaN, dnaQ, dnaT, dnaX, holA, holB, holC, holD, holE) · Replizom · DNK ligaza · DNK stega · Topoizomeraza (DNK giraza) Prokariotska DNK polimeraza: DNK polimeraza I (Klenov fragment)
Eukariotska (sinteza u S fazi)	Replikacioni faktor C (RFC1) · Endonukleaza prepusta (FEN1) · Topoizomeraza · Replikacioni protein A (RPA1) Eukariotska DNK polimeraza: delta (POLD1, POLD2, POLD3, POLD4) DNK stega (PCNA)
Oba	Kretanje: Procesivnost · DNK ligaza

Terminacija

Telomer: Telomeraza (TERT, TERC, DKC1)

B bsyn: dnk (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)