Motilin receptor

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Motilin receptor
Identifikatori
SimboliMLNR; GPR38; MTLR1
Vanjski IDOMIM: 602885 HomoloGene: 74398 IUPHAR: motilin GeneCards: MLNR Gene
Ontologija gena
Molekularna funkcija • rodopsinu-slična receptorska aktivnost
• receptorska aktivnost
• aktivnost hormon rasta-oslobađajućeg hormonskog receptora
Celularna komponenta • integralno sa membranom plazme
• membrana
Biološki proces • kontrakcija glatkog mišića
• prenos signal
• G-protein spregnuti receptor protein signalni put
• varenje
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez2862n/a
EnsemblENSG00000102539n/a
UniProtO43193n/a
RefSeq (mRNA)NM_001507n/a
RefSeq (protein)NP_001498n/a
Lokacija (UCSC)Chr 13:
48.69 - 48.69 Mb		n/a
PubMed pretraga[1]n/a

Motilin receptor je G protein-spregnuti receptor koji vezuje motilin.[1][2] Motilin je intestinalni peptid koji stimuliše kontrakcije glatkih mišića stomaka.

Literatura

  1. ↑ Depoortere I (2001). „Motilin and motilin receptors: characterization and functional significance”. Verh. K. Acad. Geneeskd. Belg. 63 (6): 511–29. PMID 11813507. 
  2. ↑ Yang X, Dong L, Yang H (2006). „[Evidence for the presence of motilin receptor and a study on the mechanism of motilin induced Ca2+ signaling in rat myenteric neurons]” (Chinese). Sichuan Da Xue Xue Bao Yi Xue Ban 37 (5): 683–6. PMID 17037727. 

Dodatna literatura

  • Smith RG, Leonard R, Bailey AR, et al. (2001). „Growth hormone secretagogue receptor family members and ligands.”. Endocrine 14 (1): 9–14. DOI:10.1385/ENDO:14:1:009. PMID 11322507. 
  • McKee KK, Tan CP, Palyha OC, et al. (1998). „Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors.”. Genomics 46 (3): 426–34. DOI:10.1006/geno.1997.5069. PMID 9441746. 
  • Feighner SD, Tan CP, McKee KK, et al. (1999). „Receptor for motilin identified in the human gastrointestinal system.”. Science 284 (5423): 2184–8. DOI:10.1126/science.284.5423.2184. PMID 10381885. 
  • Miller P, Roy A, St-Pierre S, et al. (2000). „Motilin receptors in the human antrum.”. Am. J. Physiol. Gastrointest. Liver Physiol. 278 (1): G18–23. PMID 10644557. 
  • Thielemans L, Depoortere I, Van Assche G, et al. (2001). „Demonstration of a functional motilin receptor in TE671 cells from human cerebellum.”. Brain Res. 895 (1-2): 119–28. DOI:10.1016/S0006-8993(01)02055-8. PMID 11259768. 
  • Coulie B, Matsuura B, Dong M, et al. (2001). „Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling.”. J. Biol. Chem. 276 (38): 35518–22. DOI:10.1074/jbc.M104489200. PMID 11461914. 
  • Thielemans L, Depoortere I, Vanden Broeck J, Peeters TL (2002). „The motilin pharmacophore in CHO cells expressing the human motilin receptor.”. Biochem. Biophys. Res. Commun. 293 (4): 1223–7. DOI:10.1016/S0006-291X(02)00356-X. PMID 12054506. 
  • Depoortere I, Thijs T, Thielemans L, et al. (2003). „Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum.”. J. Pharmacol. Exp. Ther. 305 (2): 660–7. DOI:10.1124/jpet.102.047563. PMID 12606621. 
  • Dunham A, Matthews LH, Burton J, et al. (2004). „The DNA sequence and analysis of human chromosome 13.”. Nature 428 (6982): 522–8. DOI:10.1038/nature02379. PMC 2665288. PMID 15057823. 
  • Matsuura B, Dong M, Naik S, et al. (2006). „Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity.”. J. Biol. Chem. 281 (18): 12390–6. DOI:10.1074/jbc.M511921200. PMID 16531413. 
  • „Motilin Receptors: Motilin”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2011-05-16. 

Spoljašnje veze

  • MeSH Motilin+receptor
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)