GPR15

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G protein-spregnuti receptor 15
Identifikatori
SimboliGPR15; MGC126828; MGC126830
Vanjski IDOMIM: 601166 MGI: 1918473 HomoloGene: 3869 IUPHAR: GPR15 GeneCards: GPR15 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu-sličnog receptora
• receptorska aktivnost
• aktivnost purinergičkog nukleotidnog receptora, G-protein spregnutog
Celularna komponenta • integralno sa ćelijskom membranom
• membrana
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez283871223
EnsemblENSG00000154165ENSMUSG00000047293
UniProtP49685n/a
RefSeq (mRNA)NM_005290XM_001002039
RefSeq (protein)NP_005281XP_001002039
Lokacija (UCSC)Chr 3:
99.73 - 99.73 Mb		Chr 16:
58.66 - 58.66 Mb
PubMed pretraga[1][2]

GPR15, G-protein spregnuti receptor 15, je protein koji je kod čoveka kodiran GPR15 genom.[1][2]

Literatura

  1. ↑ Heiber M, Marchese A, Nguyen T, Heng HH, George SR, O'Dowd BF (Feb 1997). „A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3”. Genomics 32 (3): 462–5. DOI:10.1006/geno.1996.0143. PMID 8838812. 
  2. ↑ „Entrez Gene: GPR15 G protein-coupled receptor 15”. 

Dodatna literatura

  • Cunningham AL, Li S, Juarez J, et al. (2000). „The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes.”. J. Leukoc. Biol. 68 (3): 311–7. PMID 10985245. 
  • Deng HK, Unutmaz D, KewalRamani VN, Littman DR (1997). „Expression cloning of new receptors used by simian and human immunodeficiency viruses.”. Nature 388 (6639): 296–300. DOI:10.1038/40894. PMID 9230441. 
  • Farzan M, Choe H, Martin K, et al. (1997). „Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection.”. J. Exp. Med. 186 (3): 405–11. DOI:10.1084/jem.186.3.405. PMC 2198994. PMID 9236192. 
  • Clayton F, Kotler DP, Kuwada SK, et al. (2001). „Gp120-induced Bob/GPR15 activation: a possible cause of human immunodeficiency virus enteropathy.”. Am. J. Pathol. 159 (5): 1933–9. PMC 1867054. PMID 11696454. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Croitoru-Lamoury J, Guillemin GJ, Boussin FD, et al. (2003). „Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation.”. Glia 41 (4): 354–70. DOI:10.1002/glia.10181. PMID 12555203. 
  • Maresca M, Mahfoud R, Garmy N, et al. (2003). „The virotoxin model of HIV-1 enteropathy: involvement of GPR15/Bob and galactosylceramide in the cytopathic effects induced by HIV-1 gp120 in the HT-29-D4 intestinal cell line.”. J. Biomed. Sci. 10 (1): 156–66. DOI:10.1159/000068089. PMID 12566994. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Blaak H, Boers PH, Gruters RA, et al. (2005). „CCR5, GPR15, and CXCR6 are major coreceptors of human immunodeficiency virus type 2 variants isolated from individuals with and without plasma viremia.”. J. Virol. 79 (3): 1686–700. DOI:10.1128/JVI.79.3.1686-1700.2005. PMC 544080. PMID 15650194. 
  • Cilliers T, Willey S, Sullivan WM, et al. (2005). „Use of alternate coreceptors on primary cells by two HIV-1 isolates.”. Virology 339 (1): 136–44. DOI:10.1016/j.virol.2005.05.027. PMID 15992849. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)