POLD1

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Polimeraza (DNK vođena), delta 1, katalitička podjednica
Identifikatori
SimboliPOLD1; CDC2; CRCS10; POLD
Vanjski IDOMIM: 174761 MGI: 97741 HomoloGene: 2014 GeneCards: POLD1 Gene
EC broj2.7.7.7
Ontologija gena
Molekulska funkcija • nukleotidno vezivanje
• DNK vezivanje
• hromatinsko vezivanje
Ćelijska komponenta • kompleks popravke nukleotidnim isecanjem
• nukleus
• nukleoplazma
Biološki proces • S faza mitotičkog ćelijskog ciklusa
• mitotički ćelijski ciklus
• telomerno održavanje rekombinacijom
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez542418971
EnsemblENSG00000062822ENSMUSG00000038644
UniProtP28340P52431
Ref. Sekv. (iRNK)NM_001256849NM_011131
Ref. Sekv. (protein)NP_001243778NP_035261
Lokacija (UCSC)Chr 19:
50.89 - 50.92 Mb		Chr 7:
44.53 - 44.55 Mb
PubMed pretraga[1][2]

Katalitička podjedinica DNK polimeraze delta je enzim koji je kod ljudi kodiran POLD1 genom.[1][2] Ona je komponenta kompleksa DNK polimeraza delta.

POLD1, zajedno sa enzimom POLE, je asocirana sa višestrukim adenomom.[3]

Reference

  1. ↑ Chung DW, Zhang JA, Tan CK, Davie EW, So AG, Downey KM (Feb 1992). „Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene”. Proc Natl Acad Sci U S A 88 (24): 11197–201. DOI:10.1073/pnas.88.24.11197. PMC 53101. PMID 1722322. 
  2. ↑ „Entrez Gene: POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa”. 
  3. ↑ Palles C, Cazier JB et al. Nature Genetics 2013. Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.

Literatura

  • Kemper RR, Ahn ER, Zhang P, et al. (1992). „Human DNA polymerase delta gene maps to region 19q13.3-q13.4 by in situ hybridization.”. Genomics 14 (1): 205–6. DOI:10.1016/S0888-7543(05)80311-8. PMID 1427831. 
  • Yang CL, Chang LS, Zhang P, et al. (1992). „Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase delta.”. Nucleic Acids Res. 20 (4): 735–45. DOI:10.1093/nar/20.4.735. PMC 312012. PMID 1542570. 
  • Popanda O, Thielmann HW (1992). „The function of DNA polymerases in DNA repair synthesis of ultraviolet-irradiated human fibroblasts.”. Biochim. Biophys. Acta 1129 (2): 155–60. DOI:10.1016/0167-4781(92)90480-N. PMID 1730053. 
  • Lee MY, Toomey NL (1987). „Human placental DNA polymerase delta: identification of a 170-kilodalton polypeptide by activity staining and immunoblotting.”. Biochemistry 26 (4): 1076–85. DOI:10.1021/bi00378a014. PMID 2436659. 
  • Dresler SL, Gowans BJ, Robinson-Hill RM, Hunting DJ (1989). „Involvement of DNA polymerase delta in DNA repair synthesis in human fibroblasts at late times after ultraviolet irradiation.”. Biochemistry 27 (17): 6379–83. DOI:10.1021/bi00417a028. PMID 3146346. 
  • Nishida C, Reinhard P, Linn S (1988). „DNA repair synthesis in human fibroblasts requires DNA polymerase delta.”. J. Biol. Chem. 263 (1): 501–10. PMID 3335506. 
  • Hindges R, Hübscher U (1997). „Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2).”. Genomics 44 (1): 45–51. DOI:10.1006/geno.1997.4838. PMID 9286699. 
  • Wu SM, Zhang P, Zeng XR, et al. (1998). „Characterization of the p125 subunit of human DNA polymerase delta and its deletion mutants. Interaction with cyclin-dependent kinase-cyclins.”. J. Biol. Chem. 273 (16): 9561–9. DOI:10.1074/jbc.273.16.9561. PMID 9545286. 
  • Coll JM, Hickey RJ, Cronkey EA, et al. (1998). „Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome.”. Oncol. Res. 9 (11-12): 629–39. PMID 9563011. 
  • Fox G, Popanda O, Thielmann HW (1998). „Evidence for reduced copying fidelity of DNA polymerases alpha, delta, and epsilon from Novikoff hepatoma cells.”. J. Cancer Res. Clin. Oncol. 123 (11-12): 659–68. DOI:10.1007/s004320050121. PMID 9620226. 
  • Kim ST, Lim DS, Canman CE, Kastan MB (2000). „Substrate specificities and identification of putative substrates of ATM kinase family members.”. J. Biol. Chem. 274 (53): 37538–43. DOI:10.1074/jbc.274.53.37538. PMID 10608806. 
  • Mo J, Liu L, Leon A, et al. (2000). „Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA.”. Biochemistry 39 (24): 7245–54. DOI:10.1021/bi0000871. PMID 10852724. 
  • Budworth H, Dianova II, Podust VN, Dianov GL (2002). „Repair of clustered DNA lesions. Sequence-specific inhibition of long-patch base excision repair be 8-oxoguanine.”. J. Biol. Chem. 277 (24): 21300–5. DOI:10.1074/jbc.M201918200. PMID 11923315. 
  • Ohta S, Shiomi Y, Sugimoto K, et al. (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.”. J. Biol. Chem. 277 (43): 40362–7. DOI:10.1074/jbc.M206194200. PMID 12171929. 
  • Smith RW, Nasheuer HP (2002). „Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180.”. FEBS Lett. 527 (1-3): 143–6. DOI:10.1016/S0014-5793(02)03197-6. PMID 12220650. 
  • Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M (2002). „Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication.”. Biochim. Biophys. Acta 1578 (1-3): 59–72. DOI:10.1016/S0167-4781(02)00497-9. PMID 12393188. 
  • Xie B, Mazloum N, Liu L, et al. (2002). „Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme.”. Biochemistry 41 (44): 13133–42. DOI:10.1021/bi0262707. PMID 12403614. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Shevelev IV, Ramadan K, Hübscher U (2004). „The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy.”. ScientificWorldJournal 2: 275–81. DOI:10.1100/tsw.2002.99. PMID 12806015. 
  • p
  • r
  • u
Separacija
i inicijacija
Prokariotska
(inicijacija)
Eukariotska
(priprema u
G1 fazi)
Oba
Replikacija
Prokariotska
(elongacija)
Eukariotska
(sinteza u
S fazi)
Oba
Kretanje: Procesivnost • DNK ligaza
Terminacija
B bsyn: dnk (repl, cycl, reco, repr) • tscr (fact, tcrg, nucl, rnat, rept, ptts) • tltn (risu, pttl, nexn) • dnab, rnab/runp • stru (domn, 1°, 2°, 3°, 4°)