• formiranje tiroidnog hormona • prenos signala • međućelijska signalizacija • pozitivna regulacija ćelijske proliferacije • razvoj gonade
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta
Čovek
Miš
Entrez
1081
12640
Ensembl
ENSG00000135346
ENSMUSG00000028298
UniProt
P01215
P01216
RefSeq (mRNA)
NM_000735.3
NM_009889.2
RefSeq (protein)
NP_000726.1
NP_034019.1
Lokacija (UCSC)
Chr 6: 87.8 - 87.8 Mb
Chr 4: 34.89 - 34.91 Mb
PubMed pretraga
[1]
[2]
Alfa lanac glikoproteinskih hormona je protein koji je kod ljudi kodiran CGA genom.[1]
Četiri ljudska glikoproteinska hormona: humani horionski gonadotropin (hCG), luteinizirajući hormon (LH), folikulostimulišući hormon (FSH), i tireostimulišući hormon (TSH) su dimeri koji se sastoje od alfa i beta podjedinica, koje su nekovalentno vezane. Alfa podjedinice tih hormona su skoro identične, dok su njihovi beta lanci jedinstveni i definišu biološku specifičnost. Protein kodiran ovim genom je alfa podjedinica i pripada familiji alfa lanaca glikoproteinskih hormona.[2]
Alfa lanac ima sledeću aminokiselinsku sekvencu:
NH2 - Ala - Pro - Asp - Val - Gln - Asp - Cys - Pro - Glu - Cys - Thr - Leu - Gln - Glu - Asn - Pro - Phe - Phe - Ser - Gln - Pro - Gly - Ala - Pro - Ile - Leu - Gln - Cys - Met - Gly - Cys - Cys - Phe - Ser - Arg - Ala - Tyr - Pro - Thr - Pro - Leu - Arg - Ser - Lys - Lys - Thr - Met - Leu - Val - Gln - Lys - Asn - Val - Thr - Ser - Glu - Ser - Thr - Cys - Cys - Val - Ala - Lys - Ser - Tyr - Asn - Arg - Val - Thr - Val - Met - Gly - Gly - Phe - Lys - Val - Glu - Asn - His - Thr - Ala - Cys - His - Cys - Ser - Thr - Cys - Tyr - Tyr - His - Lys - Ser - COOH
Aminokiselinska sekvena beta lanaca je:
NH2 - Ser - Lys - Glu - Pro - Leu - Arg - Pro - Arg - Cys - Arg - Pro - Ile - Asn - Ala - Thr - Leu - Ala - Val - Glu - Lys - Glu - Gly - Cys - Pro - Val - Cys - Ile - Thr - Val - Asn - Thr - Thr - Ile - Cys - Ala - Gly - Tyr - Cys - Pro - Thr - Met - Thr - Arg - Val - Leu - Gln - Gly - Val - Leu - Pro - Ala - Leu - Pro - Gln - Val - Val - Cys - Asn - Tyr - Arg - Asp - Val - Arg - Phe - Glu - Ser - Ile - Arg - Leu - Pro - Gly - Cys - Pro - Arg - Gly - Val - Asn - Pro - Val - Val - Ser - Tyr - Ala - Val - Ala - Leu - Ser - Cys - Gln - Cys - Ala - Leu - Cys - Arg - Arg - Ser - Thr - Thr - Asp - Cys - Gly - Gly - Pro - Lys - Asp - His - Pro - Leu - Thr - Cys - Asp - Asp - Pro - Arg - Phe - Gln - Asp - Ser - Ser - Ser - Ser - Lys - Ala - Pro - Pro - Pro - Ser - Leu - Pro - Ser - Pro - Ser - Arg - Leu - Pro - Gly - Pro - Ser - Asp - Thr - Pro - Ile - Leu - Pro - Gln - COOH
Reference
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Roger M, Lahlou N, Couzinet B, et al. (1990). „[Free alpha-subunit glycoprotein hormones: physiological and pathological data]”. J. Steroid Biochem.33 (4B): 763–9. DOI:10.1016/0022-4731(89)90489-5. PMID 2481154.
Pierce JG (1972). „Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones.”. Endocrinology89 (6): 1331–44. DOI:10.1210/endo-89-6-1331. PMID 5002675.
Kourides IA, Gurr JA, Wolf O (1984). „The regulation and organization of thyroid stimulating hormone genes.”. Recent Prog. Horm. Res.40: 79–120. PMID 6207569.
Miyoshi I, Kasai N, Hayashizaki Y (1994). „[Structure and regulation of human thyroid-stimulating hormone (TSH) gene]”. Nippon Rinsho52 (4): 940–7. PMID 8196184.
Barrios-De-Tomasi J, Timossi C, Merchant H, et al. (2002). „Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones.”. Mol. Cell. Endocrinol.186 (2): 189–98. DOI:10.1016/S0303-7207(01)00657-8. PMID 11900895.
Moyle WR, Bahl OP, März L (1976). „Role of carbohydrate of human chorionic gonadotropin in the mechanism of hormone action.”. J. Biol. Chem.250 (23): 9163–9. PMID 172504.
Fiddes JC, Goodman HM (1979). „Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin.”. Nature281 (5730): 351–6. DOI:10.1038/281351a0. PMID 481597.
Sairam MR, Li CH (1977). „Human pituitary thyrotropin. The primary structure of the alpha and beta subunits.”. Can. J. Biochem.55 (7): 755–60. DOI:10.1139/o77-108. PMID 890569.
Morgan FJ, Birken S, Canfield RE (1975). „The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit.”. J. Biol. Chem.250 (13): 5247–58. PMID 1150658.
Rathnam P, Saxena BB (1975). „Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands. I. alpha subunit.”. J. Biol. Chem.250 (17): 6735–46. PMID 1158880.
Weisshaar G, Hiyama J, Renwick AG, Nimtz M (1991). „NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin.”. Eur. J. Biochem.195 (1): 257–68. DOI:10.1111/j.1432-1033.1991.tb15702.x. PMID 1991473.
Sakakibara R, Yokoo Y, Yoshikoshi K, et al. (1988). „Subcellular localization of intracellular forms of human chorionic gonadotropin in first trimester placenta.”. J. Biochem.102 (5): 993–1001. PMID 2449427.
Matzuk MM, Keene JL, Boime I (1989). „Site specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction.”. J. Biol. Chem.264 (5): 2409–14. PMID 2536708.
Lustbader JW, Birken S, Pileggi NF, et al. (1990). „Crystallization and characterization of human chorionic gonadotropin in chemically deglycosylated and enzymatically desialylated states.”. Biochemistry28 (24): 9239–43. DOI:10.1021/bi00450a001. PMID 2611225.
Harris DC, Machin KJ, Evin GM, et al. (1989). „Preliminary X-ray diffraction analysis of human chorionic gonadotropin.”. J. Biol. Chem.264 (12): 6705–6. PMID 2708337.
Hayashizaki Y, Miyai K, Kato K, Matsubara K (1985). „Molecular cloning of the human thyrotropin-beta subunit gene.”. FEBS Lett.188 (2): 394–400. DOI:10.1016/0014-5793(85)80409-9. PMID 3839756.
Bellisario R, Carlsen RB, Bahl OP (1973). „Human chorionic gonadotropin. Linear amino acid sequence of the alpha subunit.”. J. Biol. Chem.248 (19): 6796–809. PMID 4745444.
Shome B, Parlow AF (1974). „Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa).”. J. Clin. Endocrinol. Metab.39 (1): 199–202. DOI:10.1210/jcem-39-1-199. PMID 4835135.
