NDC1

識別子

記号

NDC1, NET3, TMEM48, NDC1 transmembrane nucleoporin

外部ID

OMIM: 610115 MGI: 1920037 HomoloGene: 41224 GeneCards: NDC1

遺伝子の位置 (ヒト)

染色体	1番染色体 (ヒト)^[1]

バンド	データ無し	開始点	53,765,478 bp^[1]
バンド	データ無し	終点	53,838,463 bp^[1]

遺伝子の位置 (マウス)

染色体	4番染色体 (マウス)^[2]

バンド	データ無し	開始点	107,224,981 bp^[2]
バンド	データ無し	終点	107,273,543 bp^[2]

RNA発現パターン

さらなる参照発現データ

遺伝子オントロジー
分子機能	• structural constituent of nuclear pore
細胞の構成要素	• 細胞質 • integral component of membrane • 核膜 • nuclear envelope • 膜 • 細胞膜 • 核膜孔 • actin cytoskeleton • 細胞核 • スピンドル極体 • nuclear pore transmembrane ring • 宿主細胞
生物学的プロセス	• mRNA transport • nuclear pore complex assembly • viral transcription • protein sumoylation • mitotic nuclear membrane disassembly • homologous chromosome pairing at meiosis • 精子形成 • タンパク質輸送 • regulation of cellular response to heat • viral process • mRNA export from nucleus • intracellular transport of virus • tRNA export from nucleus • spindle pole body duplication • regulation of gene silencing by miRNA • regulation of glycolytic process • 輸送 • nuclear pore organization
出典:Amigo / QuickGO

オルソログ

種

ヒト

マウス

Entrez


55706


72787

Ensembl


ENSG00000058804


ENSMUSG00000028614

UniProt


Q9BTX1


Q8VCB1

RefSeq
(mRNA)


NM_001168551 NM_018087


NM_028355

RefSeq
(タンパク質)


NP_001162023 NP_060557


NP_082631

場所
(UCSC)

Chr 1: 53.77 – 53.84 Mb

Chr 1: 107.22 – 107.27 Mb

PubMed検索

^[3]

^[4]

ウィキデータ

閲覧/編集ヒト

閲覧/編集マウス

ヌクレオポリンNDC1（英語: Nucleoporin NDC1）は、ヒトにおいてTMEM48 遺伝子にコードされているタンパク質である^[5]^[6]^[7]。核膜孔複合体にアラジン（英語版）を固定する^[8]。　

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000058804 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028614 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue”. Anat Rec A Discov Mol Cell Evol Biol 288 (7): 681–94. (Aug 2006). doi:10.1002/ar.a.20335. PMC 3049984. PMID 16779818. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049984/.
^ “Nuclear membrane proteins with potential disease links found by subtractive proteomics”. Science 301 (5638): 1380–2. (Sep 2003). doi:10.1126/science.1088176. PMID 12958361.
^ “Entrez Gene: TMEM48 transmembrane protein 48”. 2019年7月23日閲覧。
^ Kind, Barbara; Koehler, Katrin; Lorenz, Mike; Huebner, Angela (December 2009). “The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope”. Biochemical and Biophysical Research Communications 390 (2): 205–210. doi:10.1016/j.bbrc.2009.09.080.

参考文献

“Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. (2003). doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
“Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. (2004). doi:10.1038/ng1285. PMID 14702039.
“The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. (2004). doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
“Phosphoproteome analysis of the human mitotic spindle.”. Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. (2006). doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459365/.
“The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells.”. Mol. Cell 22 (1): 93–103. (2006). doi:10.1016/j.molcel.2006.02.015. PMID 16600873.
“NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes.”. J. Cell Biol. 173 (4): 509–19. (2006). doi:10.1083/jcb.200601001. PMC 2063861. PMID 16702233. http://pubman.mpdl.mpg.de/pubman/item/escidoc:596272/component/escidoc:596271/298064.pdf.
“The DNA sequence and biological annotation of human chromosome 1.”. Nature 441 (7091): 315–21. (2006). doi:10.1038/nature04727. PMID 16710414.
“Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”. Cell 127 (3): 635–48. (2006). doi:10.1016/j.cell.2006.09.026. PMID 17081983.