WNT9B

Protein-coding gene in the species Homo sapiens

WNT9B

Identifiers

Aliases

WNT9B, WNT14B, WNT15, Wnt family member 9B

External IDs

OMIM: 602864; MGI: 1197020; HomoloGene: 2551; GeneCards: WNT9B; OMA:WNT9B - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q21.32	Start	46,833,201 bp^[1]
Band	17q21.32	End	46,886,730 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11 E1\|11 67.47 cM	Start	103,618,190 bp^[2]
Band	11 E1\|11 67.47 cM	End	103,640,647 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gonad

duodenum

human kidney

prefrontal cortex

placenta

apex of heart

superior frontal gyrus

primary visual cortex

right frontal lobe

right auricle

Top expressed in

interventricular septum

medullary collecting duct

cortical collecting duct

surface ectoderm

labioscrotal swelling

semi-lunar valve

Cloacal membrane

lateral geniculate nucleus

maxillary prominence

mandibular prominence

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	frizzled binding signaling receptor binding co-receptor binding receptor ligand activity
Cellular component	extracellular region extracellular space
Biological process	kidney morphogenesis cell-cell signaling cellular response to starvation mesonephric duct formation multicellular organism development male genitalia development cornea development in camera-type eye branching morphogenesis of an epithelial tube kidney rudiment formation collecting duct development regulation of asymmetric cell division embryonic cranial skeleton morphogenesis kidney development Wnt signaling pathway, planar cell polarity pathway cellular response to retinoic acid mesenchymal stem cell maintenance involved in nephron morphogenesis establishment of planar polarity involved in nephron morphogenesis nephron tubule morphogenesis roof of mouth development metanephric tubule development in utero embryonic development regulation of tube size mesonephric tubule development uterus morphogenesis response to retinoic acid regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis cell fate commitment branching involved in ureteric bud morphogenesis positive regulation of catalytic activity metanephric tubule formation regulation of protein phosphorylation negative regulation of stem cell population maintenance midbrain dopaminergic neuron differentiation non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Wnt signaling pathway neuron differentiation regulation of signaling receptor activity canonical Wnt signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7484


22412

Ensembl


ENSG00000158955 ENSG00000276799


ENSMUSG00000018486

UniProt


O14905


O35468

RefSeq (mRNA)


NM_003396 NM_001320458


NM_011719

RefSeq (protein)


NP_001307387 NP_003387


NP_035849

Location (UCSC)

Chr 17: 46.83 – 46.89 Mb

Chr 11: 103.62 – 103.64 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Protein Wnt-9b (formerly Wnt15^[5]) is a protein that in humans is encoded by the WNT9B gene.^[6]

The Wnt family of genes produce glycolipoproteins that are involved with signaling and developmental processes. Like other Wnt genes, Wnt-9b codes for the Wnt-9b protein which participates in the canonical Wnt/β-catenin signaling pathway. Wnt-9b is a gene found on chromosome 17 in region 17q21. It can be traced to function in the establishment of the kidneys, because Wnt9 is critical for morphogenesis of the nephron.^[7] This gene can impact kidney function in more than one way. Improper expression of the gene can cause cyst development on the kidney tubules, and in mice, mutant Wnt9 genes that cause lower protein concentrations resulted in failure of the kidneys to thrive shortly after birth.^[8] Wnt-9b is a gene that often expressed in the epithelial cells of the Wolfian duct in early male and female embryos. In the embryos, Wnt11 is expressed at the branching points of the kidney tubules while Wnt-9b is expressed in a higher concentration at the stalk of the tubules.^[9] Wnt-9b has also been tied to the involvement of neural differentiation by induction of retinoic acid, according to the NCBI.^[10]

References

^ ^a ^b ^c ENSG00000276799 GRCh38: Ensembl release 89: ENSG00000158955, ENSG00000276799 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018486 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Garriock RJ, Warkman AS, Meadows SM, D'Agostino S, Krieg PA (2007). "Census of vertebrate Wnt genes: isolation and developmental expression of Xenopus Wnt2, Wnt3, Wnt9a, Wnt9b, Wnt10a, and Wnt16". Developmental Dynamics. 236 (5): 1249–58. doi:10.1002/dvdy.21156. PMID 17436276. S2CID 21016668.
^ "Entrez Gene: Wnt9b wingless-type MMTV integration site family, member 9B".
^ Karner C, Chirumamilla R, Aoki S, et al. (2009). "Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis". Nat Genet. 41 (7): 793–799. doi:10.1038/ng.400. PMC 2761080. PMID 19543268.
^ Karner C, Chirumamilla R, Aoki S, et al. (2009). "Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis". Nat Genet. 41 (7): 793–799. doi:10.1038/ng.400. PMC 2761080. PMID 19543268.
^ Carroll T, Park J, Hayashi S, Majumdar A, McMahon A, et al. (2005). "Wnt9b Plays a Central Role in the Regulation of Mesenchymal to Epithelial Transitions Underlying Organogenesis of the Mammalian Urogenital System". Developmental Cell. 9 (2): 283–292. doi:10.1016/j.devcel.2005.05.016. PMID 16054034.
^ "WNT9B Wnt family member 9B [Homo sapiens (human)]". NCBI Genes & Expression. 2021-04-06. Retrieved 2021-04-14.