TNRC6B

Protein-coding gene in the species Homo sapiens
TNRC6B
Identifiers
AliasesTNRC6B, trinucleotide repeat containing 6B, trinucleotide repeat containing adaptor 6B, GDSBA
External IDsOMIM: 610740; MGI: 2443730; HomoloGene: 66194; GeneCards: TNRC6B; OMA:TNRC6B - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for TNRC6B
Genomic location for TNRC6B
Band22q13.1Start40,044,817 bp[1]
End40,335,808 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for TNRC6B
Genomic location for TNRC6B
Band15|15 E1Start80,595,514 bp[2]
End80,825,286 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • epithelium of nasopharynx

  • sural nerve

  • oocyte

  • caput epididymis

  • trabecular bone

  • secondary oocyte

  • seminal vesicula

  • nipple

  • tail of epididymis
Top expressed in
  • zygote

  • secondary oocyte

  • granulocyte

  • genital tubercle

  • tibiofemoral joint

  • tail of embryo

  • neural layer of retina

  • human fetus

  • lens

  • inferior colliculus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nucleic acid binding
  • RNA binding
Cellular component
  • cytoplasm
  • cytosol
  • P-body
  • nucleoplasm
Biological process
  • RNA interference
  • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  • regulation of translation
  • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • gene silencing
  • miRNA-mediated gene silencing by inhibition of translation
  • Wnt signaling pathway, calcium modulating pathway
  • regulation of megakaryocyte differentiation
  • positive regulation of gene expression
  • negative regulation of gene expression
  • gene silencing by miRNA
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23112

213988

Ensembl

ENSG00000100354

ENSMUSG00000047888

UniProt

Q9UPQ9

Q8BKI2

RefSeq (mRNA)

NM_015088
NM_001024843
NM_001162501

NM_144812
NM_177124

RefSeq (protein)

NP_001020014
NP_001155973
NP_055903

NP_659061
NP_796098

Location (UCSC)Chr 22: 40.04 – 40.34 MbChr 15: 80.6 – 80.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Trinucleotide repeat-containing gene 6B protein is a protein that in humans is encoded by the TNRC6B gene.[5]

Interactions

TNRC6B has been shown to interact with EIF2C2.[6] It is also known to associate with argonaute proteins and has been shown to be required for miRNA-guided gene silencing in HeLa cells.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100354 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047888 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: TNRC6B trinucleotide repeat containing 6B".
  6. ^ Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (October 2007). "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. Struct. Mol. Biol. 14 (10): 897–903. doi:10.1038/nsmb1302. PMID 17891150. S2CID 8136380.
  7. ^ Meister G, Landthaler M, Peters L, Chen PY, Urlaub H, Lührmann R, Tuschl T (December 2005). "Identification of novel argonaute-associated proteins". Curr. Biol. 15 (23): 2149–55. doi:10.1016/j.cub.2005.10.048. hdl:11858/00-001M-0000-0012-E763-B. PMID 16289642. S2CID 2740901.

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77. doi:10.1006/geno.1999.5855. PMID 10409428.
  • Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Schneider MD, Najand N, Chaker S, et al. (2006). "Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development". J. Cell Biol. 174 (3): 349–58. doi:10.1083/jcb.200512103. PMC 2064231. PMID 16880270.


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