STK17A

Protein-coding gene in the species Homo sapiens
STK17A
Identifiers
AliasesSTK17A, DRAK1, serine/threonine kinase 17a
External IDsOMIM: 604726; HomoloGene: 55846; GeneCards: STK17A; OMA:STK17A - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for STK17A
Genomic location for STK17A
Band7p13Start43,582,758 bp[1]
End43,650,713 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lymph node

  • epithelium of nasopharynx

  • granulocyte

  • appendix

  • blood

  • bone marrow

  • ganglionic eminence

  • ventricular zone

  • vena cava

  • Achilles tendon
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • kinase activity
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • protein serine/threonine kinase activity
  • ATP binding
Cellular component
  • nucleus
  • plasma membrane
  • nuclear speck
Biological process
  • positive regulation of apoptotic process
  • positive regulation of fibroblast apoptotic process
  • protein phosphorylation
  • intracellular signal transduction
  • regulation of reactive oxygen species metabolic process
  • phosphorylation
  • apoptotic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9263

n/a

Ensembl

ENSG00000164543

n/a

UniProt

Q9UEE5

n/a

RefSeq (mRNA)

NM_004760

n/a

RefSeq (protein)

NP_004751

n/a

Location (UCSC)Chr 7: 43.58 – 43.65 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Serine/threonine kinase 17a is a protein that in humans is encoded by the STK17A gene.[3]

Function

This gene is a member of the death-associated protein (DAP) kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.[3]

In a recent study the gene (among others) shows a major role in centenarians longer lifespan.[4]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164543 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: Serine/threonine kinase 17a".
  4. ^ Garagnani P, Marquis J, Delledonne M, Pirazzini C, Marasco E, Kwiatkowska KM, et al. (May 2021). Tyler JK, Suh Y, Shuldiner AR (eds.). "Whole-genome sequencing analysis of semi-supercentenarians". eLife. 10: e57849. doi:10.7554/eLife.57849. PMC 8096429. PMID 33941312.

Further reading

  • Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, et al. (September 2009). "The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors". PLOS Genetics. 5 (9): e1000637. doi:10.1371/journal.pgen.1000637. PMC 2727793. PMID 19730683.
  • Sanjo H, Kawai T, Akira S (October 1998). "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis". The Journal of Biological Chemistry. 273 (44): 29066–71. doi:10.1074/jbc.273.44.29066. PMID 9786912.
  • Mao P, Hever MP, Niemaszyk LM, Haghkerdar JM, Yanco EG, Desai D, et al. (June 2011). "Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells". The Journal of Biological Chemistry. 286 (22): 19381–91. doi:10.1074/jbc.M111.218040. PMC 3103316. PMID 21489989.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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