Protein-coding gene in the species Homo sapiens
| SOSTDC1 |
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| Identifiers |
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| Aliases | SOSTDC1, ECTODIN, USAG1, CDA019, DAND7, sclerostin domain containing 1 |
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| External IDs | OMIM: 609675; MGI: 1913292; HomoloGene: 9154; GeneCards: SOSTDC1; OMA:SOSTDC1 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 7 (human)[1] |
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| | Band | 7p21.2 | Start | 16,461,481 bp[1] |
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| End | 16,530,580 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 12 (mouse)[2] |
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| | Band | 12|12 A3 | Start | 36,364,138 bp[2] |
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| End | 36,368,451 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - retinal pigment epithelium
- hair follicle
- Epithelium of choroid plexus
- parotid gland
- skin of thigh
- skin of arm
- lower lobe of lung
- rectum
- sperm
- endothelial cell
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| | Top expressed in | - Epithelium of choroid plexus
- molar
- retinal pigment epithelium
- lumbar spinal ganglion
- sciatic nerve
- lip
- right kidney
- lateral recess
- human kidney
- Gonadal ridge
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - BMP binding
- BMP receptor activity
| | Cellular component | - extracellular region
- extracellular space
| | Biological process | - pattern specification process
- odontogenesis of dentin-containing tooth
- hair follicle morphogenesis
- mammary gland bud morphogenesis
- negative regulation of cell fate commitment
- Wnt signaling pathway
- negative regulation of canonical Wnt signaling pathway
- negative regulation of Wnt signaling pathway
- BMP signaling pathway
- negative regulation of BMP signaling pathway
- negative regulation of myoblast differentiation
- negative regulation of determination of dorsal identity
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 7: 16.46 – 16.53 Mb | Chr 12: 36.36 – 36.37 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene.[5]
Function
This gene is a member of the sclerostin family and encodes Uterine sensitization-associated gene-1 (USAG-1), an N-glycosylated, secreted protein with a C-terminal, cystine, knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.[5]
Inhibition of USAG-1 is of interest as a potential means of stimulating tooth regrowth for dentistry.[6][7][8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000171243 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036169 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: SOSTDC1 sclerostin domain containing 1".
- ^ Murashima-Suginami A, Kiso H, Tokita Y, Mihara E, Nambu Y, Uozumi R, Tabata Y, Bessho K, Takagi J, Sugai M, Takahashi K (February 2021). "Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling". Science Advances. 7 (7). doi:10.1126/sciadv.abf1798. PMC 7880588. PMID 33579703.
- ^ Ravi V, Murashima-Suginami A, Kiso H, Tokita Y, Huang CL, Bessho K, Takagi J, Sugai M, Tabata Y, Takahashi K (March 2023). "Advances in tooth agenesis and tooth regeneration". Regenerative Therapy. 22: 160–168. doi:10.1016/j.reth.2023.01.004. PMC 9931762. PMID 36819612.
- ^ "World's 1st 'tooth regrowth' medicine moves toward clinical trials in Japan". Mainichi. 12 June 2023.
Further reading
- Yanagita M (June 2005). "BMP antagonists: their roles in development and involvement in pathophysiology". Cytokine & Growth Factor Reviews. 16 (3): 309–17. doi:10.1016/j.cytogfr.2005.02.007. PMID 15951218.
- Laurikkala J, Kassai Y, Pakkasjärvi L, Thesleff I, Itoh N (December 2003). "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot". Developmental Biology. 264 (1): 91–105. doi:10.1016/j.ydbio.2003.08.011. PMID 14623234.
- Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T (April 2004). "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney". Biochemical and Biophysical Research Communications. 316 (2): 490–500. doi:10.1016/j.bbrc.2004.02.075. PMID 15020244.
- Goto M, Eddy EM (October 2004). "Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20". The Journal of Biological Chemistry. 279 (40): 42128–38. doi:10.1074/jbc.M403190200. PMID 15280373.
