SIRPG

Protein-coding gene in the species Homo sapiens
SIRPG
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2JJW, 4I2X

Identifiers
AliasesSIRPG, CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1, signal regulatory protein gamma
External IDsOMIM: 605466; MGI: 108563; HomoloGene: 56809; GeneCards: SIRPG; OMA:SIRPG - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SIRPG
Genomic location for SIRPG
Band20p13Start1,629,152 bp[1]
End1,657,779 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SIRPG
Genomic location for SIRPG
Band2 F1|2 63.19 cMStart129,434,755 bp[2]
End129,474,148 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • thymus

  • testicle

  • lymph node

  • granulocyte

  • blood

  • appendix

  • spleen

  • mucosa of transverse colon

  • left testis

  • right testis
Top expressed in
  • stroma of bone marrow

  • granulocyte

  • prefrontal cortex

  • superior frontal gyrus

  • primary visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • cerebellar cortex

  • tibiofemoral joint

  • perirhinal cortex

  • entorhinal cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • intracellular anatomical structure
Biological process
  • cell-cell signaling
  • cell adhesion
  • intracellular signal transduction
  • positive regulation of T cell activation
  • leukocyte migration
  • positive regulation of cell population proliferation
  • negative regulation of cell population proliferation
  • positive regulation of cell-cell adhesion
  • positive regulation of phagocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55423

19261

Ensembl

ENSG00000089012

ENSMUSG00000037902

UniProt

Q9P1W8

P97797

RefSeq (mRNA)

NM_001039508
NM_018556
NM_080816

NM_001177646
NM_001177647
NM_001291019
NM_001291020
NM_001291021

NM_001291022
NM_007547
NM_001355158
NM_001355160

RefSeq (protein)

NP_001034597
NP_061026
NP_543006

NP_001171118
NP_001277948
NP_001277949
NP_001277950
NP_001277951

NP_031573
NP_001342087
NP_001342089

Location (UCSC)Chr 20: 1.63 – 1.66 MbChr 2: 129.43 – 129.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene.[5][6][7] SIRPG has also recently been designated CD172G (cluster of differentiation 172G).

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000089012 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037902 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ichigotani Y, Matsuda S, Machida K, Oshima K, Iwamoto T, Yamaki K, Hayakawa T, Hamaguchi M (Jan 2001). "Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family". J Hum Genet. 45 (6): 378–82. doi:10.1007/s100380070013. PMID 11185750.
  6. ^ van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (Dec 2005). "A nomenclature for signal regulatory protein family members". J Immunol. 175 (12): 7788–9. doi:10.4049/jimmunol.175.12.7788. PMID 16339511.
  7. ^ a b "Entrez Gene: SIRPG signal-regulatory protein gamma".

Further reading

  • Kharitonenkov A, Chen Z, Sures I, et al. (1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature. 386 (6621): 181–6. Bibcode:1997Natur.386..181K. doi:10.1038/386181a0. PMID 9062191. S2CID 4259314.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Brooke G, Holbrook JD, Brown MH, Barclay AN (2004). "Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family". J. Immunol. 173 (4): 2562–70. doi:10.4049/jimmunol.173.4.2562. PMID 15294972.
  • Piccio L, Vermi W, Boles KS, et al. (2006). "Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation". Blood. 105 (6): 2421–7. doi:10.1182/blood-2004-07-2823. PMID 15383453.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Signal-regulatory protein gamma (SIRPG)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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