PLEKHM2

Protein-coding gene in the species Homo sapiens
PLEKHM2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3CXB, 3HW2, 3ZFW

Identifiers
AliasesPLEKHM2, SKIP, pleckstrin homology and RUN domain containing M2
External IDsOMIM: 609613; MGI: 1916832; HomoloGene: 19575; GeneCards: PLEKHM2; OMA:PLEKHM2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PLEKHM2
Genomic location for PLEKHM2
Band1p36.21Start15,684,320 bp[1]
End15,734,769 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for PLEKHM2
Genomic location for PLEKHM2
Band4|4 D3Start141,353,045 bp[2]
End141,392,210 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right frontal lobe

  • apex of heart

  • cingulate gyrus

  • anterior cingulate cortex

  • gastrocnemius muscle

  • muscle of thigh

  • prefrontal cortex

  • right hemisphere of cerebellum

  • stromal cell of endometrium

  • Brodmann area 9
Top expressed in
  • interventricular septum

  • primary visual cortex

  • superior frontal gyrus

  • muscle of thigh

  • cerebellar cortex

  • genital tubercle

  • lip

  • spermatid

  • dentate gyrus of hippocampal formation granule cell

  • neural layer of retina
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • kinesin binding
Cellular component
  • cytoplasm
  • endosome membrane
Biological process
  • positive regulation of membrane tubulation
  • Golgi organization
  • regulation of protein localization
  • lysosome localization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23207

69582

Ensembl

ENSG00000116786

ENSMUSG00000028917

UniProt

Q8IWE5

Q80TQ5

RefSeq (mRNA)

NM_015164

NM_001033150
NM_001347237

RefSeq (protein)

NP_055979

NP_001028322
NP_001334166

Location (UCSC)Chr 1: 15.68 – 15.73 MbChr 4: 141.35 – 141.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pleckstrin homology domain-containing family M member 2 is a protein that in humans is encoded by the PLEKHM2 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116786 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028917 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: pleckstrin homology domain containing, family M (with RUN domain) member 2". Retrieved 2011-08-30.

Further reading

  • Boucrot E, Henry T, Borg JP, Gorvel JP, Méresse S (May 2005). "The intracellular fate of Salmonella depends on the recruitment of kinesin". Science. 308 (5725): 1174–8. Bibcode:2005Sci...308.1174B. doi:10.1126/science.1110225. PMID 15905402. S2CID 41055820.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.