PLEKHA6

Protein-coding gene in the species Homo sapiens
PLEKHA6
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2D9Y, 2YRY

Identifiers
AliasesPLEKHA6, PEPP-3, PEPP3, pleckstrin homology domain containing A6
External IDsOMIM: 607771; MGI: 2388662; HomoloGene: 137310; GeneCards: PLEKHA6; OMA:PLEKHA6 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PLEKHA6
Genomic location for PLEKHA6
Band1q32.1Start204,218,853 bp[1]
End204,377,665 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for PLEKHA6
Genomic location for PLEKHA6
Band1|1 E4Start133,164,210 bp[2]
End133,303,435 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • C1 segment

  • Brodmann area 23

  • right hemisphere of cerebellum

  • rectum

  • middle temporal gyrus

  • mucosa of transverse colon

  • endothelial cell

  • primary visual cortex

  • right frontal lobe

  • apex of heart
Top expressed in
  • interventricular septum

  • spermatid

  • neural layer of retina

  • zygote

  • visual cortex

  • primary visual cortex

  • right kidney

  • superior frontal gyrus

  • cerebellar cortex

  • deep cerebellar nuclei
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

22874

240753

Ensembl

ENSG00000143850

ENSMUSG00000041757

UniProt

Q9Y2H5

Q7TQG1

RefSeq (mRNA)

NM_014935
NM_138480

NM_001160268
NM_182930

RefSeq (protein)

NP_055750

NP_001153740
NP_891846

Location (UCSC)Chr 1: 204.22 – 204.38 MbChr 1: 133.16 – 133.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pleckstrin homology domain-containing family A member 6 is a protein that in humans is encoded by the PLEKHA6 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143850 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041757 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (Jan 2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
  6. ^ "Entrez Gene: PLEKHA6 pleckstrin homology domain containing, family A member 6".

Further reading

  • Clark TA, Schweitzer AC, Chen TX, et al. (2007). "Discovery of tissue-specific exons using comprehensive human exon microarrays". Genome Biol. 8 (4): R64. doi:10.1186/gb-2007-8-4-r64. PMC 1896007. PMID 17456239.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q9Y2H5 (Pleckstrin homology domain-containing family A member 6) at the PDBe-KB.
  • v
  • t
  • e
  • 2d9y: Solution structure of the PH domain of PEPP-3 from human
    2d9y: Solution structure of the PH domain of PEPP-3 from human


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