PCGEM1

Identifiers

Aliases

PCGEM1, LINC00071, NCRNA00071, PCAT9, prostate-specific transcript (non-protein coding), prostate-specific transcript, PCGEM1 prostate-specific transcript

External IDs

OMIM: 605443; GeneCards: PCGEM1; OMA:PCGEM1 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q32.3	Start	192,749,845 bp^[1]
Band	2q32.3	End	192,776,899 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

prostate

epithelium of colon

prefrontal cortex

monocyte

reproductive organ

amygdala

islet of Langerhans

olfactory zone of nasal mucosa

primary visual cortex

n/a

More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


64002


n/a

Ensembl


ENSG00000227418


n/a

UniProt


n a


n/a

RefSeq (mRNA)


n/a


n/a

RefSeq (protein)


n/a


n/a

Location (UCSC)

Chr 2: 192.75 – 192.78 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Prostate-specific transcript 1
Predicted secondary structure and sequence conservation of PCGEM1
Identifiers
Symbol	PCGEM1
Rfam	RF01981
Other data
RNA type	Gene;
Domain(s)	Eukaryota;
GO	GO:0042981
SO	SO:0001463
PDB structures	PDBe

Prostate-specific transcript 1 (non-protein coding), also known as PCGEM1, is a long non-coding RNA gene. In humans, it is located on chromosome 2q32. It is over-expressed in prostate cancer.^[3]^[4] In a study of prostate tumours from 88 men, levels of PCGEM1 were found to be higher in prostate cancer cells in African-American men than in Caucasian-American men. The mortality rate of prostate cancer is highest in African-American men.^[5]

PCGEM1 inhibits doxorubicin-induced apoptosis of cells, via delayed induction of p53 and p21.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000227418 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Srikantan V, Zou Z, Petrovics G, et al. (October 2000). "PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer". Proc. Natl. Acad. Sci. U.S.A. 97 (22): 12216–12221. Bibcode:2000PNAS...9712216S. doi:10.1073/pnas.97.22.12216. PMC 17321. PMID 11050243.
^ Bialkowska-Hobrzanska H, Driman DK, Fletcher R, Harry V, Razvi H (February 2006). "Expression of human telomerase reverse transcriptase, Survivin, DD3 and PCGEM1 messenger RNA in archival prostate carcinoma tissue". Can J Urol. 13 (1): 2967–2974. PMID 16515751.
^ Petrovics G, Zhang W, Makarem M, et al. (January 2004). "Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients". Oncogene. 23 (2): 605–611. doi:10.1038/sj.onc.1207069. PMID 14724589.
^ Fu X, Ravindranath L, Tran N, Petrovics G, Srivastava S (March 2006). "Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1". DNA Cell Biol. 25 (3): 135–141. doi:10.1089/dna.2006.25.135. PMID 16569192.