Nalorphine dinicotinate

Chemical compound

None

Legal statusLegal status

In general: ℞ (Prescription only)

Identifiers

IUPAC name

(5α,6α)-17-allyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diyl dinicotinate

CAS Number

3194-25-0

PubChem CID

3083791

ChemSpider

2340945

CompTox Dashboard (EPA)

DTXSID30953838

Chemical and physical dataFormulaC₃₁H₂₇N₃O₅Molar mass521.573 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

O=C(O[C@H]2\C=C/[C@H]6[C@@H]5N(CC[C@@]61c4c(O[C@H]12)c(OC(=O)c3cccnc3)ccc4C5)C\C=C)c7cccnc7

InChI

InChI=1S/C31H27N3O5/c1-2-14-34-15-11-31-22-8-10-25(38-30(36)21-6-4-13-33-18-21)28(31)39-27-24(9-7-19(26(27)31)16-23(22)34)37-29(35)20-5-3-12-32-17-20/h2-10,12-13,17-18,22-23,25,28H,1,11,14-16H2/t22-,23+,25-,28-,31-/m0/s1
Key:BFYWWTIGNJJAHF-LTQSXOHQSA-N

Nalorphine dinicotinate (trade name Nimelan), also known as N-allylnormorphine dinicotinate, dinicotinoylnalorphine, or niconalorphine, is a semisynthetic, mixed opioid agonist-antagonist which is described as a narcotic antagonist but may produce limited analgesia and sedation at higher doses in opioid naive patients (with limited euphoria and dependence liability).^[1]^[2] It is the 3,6-dinicotinate ester of nalorphine, and is therefore the nalorphine analogue of nicomorphine (which is the 3,6-dinicotinate ester of morphine).

As nalorphine dinicotinate is only regulated at the Rx (prescription required) drug, it would be legal to possess with a valid prescription should a patient manage to acquire it.^{[citation needed]}

References

^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 851–. ISBN 978-1-4757-2085-3.
^ Wingard LB (1991). Human pharmacology: molecular-to-clinical. Mosby-Year Book. ISBN 978-0-8016-5632-3. Retrieved 11 May 2012.

Antidotes (V03AB)

Nervous
system

Alcohol intoxication	Metadoxine Thiamine
Barbiturate overdose	Bemegride Ethamivan
Benzodiazepine overdose	Cyprodenate Flumazenil
GHB overdose	Physostigmine SCH-50911
Nerve agent / Organophosphate poisoning	Atropine^# Biperiden Diazepam^# Oximes Obidoxime Pralidoxime see also: Cholinesterase
Opioid overdose	Diprenorphine Doxapram Nalmefene Nalorphine Naloxone^# Naltrexone
Reversal of neuromuscular blockade	Sugammadex

Circulatory
system

Beta blocker	Glucagon
Digoxin toxicity	Digoxin immune fab
Anticoagulants	against direct Xa inhibitors (Andexanet alfa) against heparin (Protamine^#)

Other

Arsenic poisoning	Dimercaprol^# Succimer
Cyanide poisoning	4-Dimethylaminophenol Hydroxocobalamin nitrite Amyl nitrite Sodium nitrite^# Sodium thiosulfate^#
Hydrofluoric acid	Calcium gluconate^#
Methanol / Ethylene glycol poisoning	Primary alcohols: Ethanol Fomepizole
Paracetamol toxicity (Acetaminophen)	Acetylcysteine^# Glutathione Methionine^#
Toxic metals (cadmium lead mercury thallium)	Dimercaprol^# Edetates Prussian blue^#
Other	iodine-131 Potassium iodide Methylthioninium chloride^# oxidizing agent Potassium permanganate Prednisolone/promethazine