MLLT6

Protein-coding gene in the species Homo sapiens
MLLT6
Identifiers
AliasesMLLT6, AF17, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6, PHD finger containing
External IDsOMIM: 600328; MGI: 1935145; HomoloGene: 31347; GeneCards: MLLT6; OMA:MLLT6 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for MLLT6
Genomic location for MLLT6
Band17q12Start38,705,273 bp[1]
End38,729,795 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for MLLT6
Genomic location for MLLT6
Band11 D|11 61.05 cMStart97,554,240 bp[2]
End97,576,289 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • pituitary gland

  • left ovary

  • right lobe of thyroid gland

  • right ovary

  • granulocyte

  • sural nerve

  • anterior pituitary

  • left lobe of thyroid gland

  • appendix
Top expressed in
  • neural layer of retina

  • ciliary body

  • mesenteric lymph nodes

  • retinal pigment epithelium

  • vestibular membrane of cochlear duct

  • dorsal striatum

  • Region I of hippocampus proper

  • olfactory tubercle

  • habenula

  • superior colliculus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • metal ion binding
  • protein binding
  • nucleosome binding
  • histone binding
Cellular component
  • nucleus
Biological process
  • regulation of transcription, DNA-templated
  • renal system process
  • excretion
  • positive regulation of sodium ion transport
  • negative regulation of urine volume
  • renal sodium excretion
  • renal potassium excretion
  • positive regulation of transcription by RNA polymerase II
  • negative regulation of histone H3-K79 methylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4302

246198

Ensembl

ENSG00000275023
ENSG00000275851

ENSMUSG00000038437

UniProt

P55198
Q6P2C6

n/a

RefSeq (mRNA)

NM_005937

NM_139311

RefSeq (protein)

NP_005928

n/a

Location (UCSC)Chr 17: 38.71 – 38.73 MbChr 11: 97.55 – 97.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MLLT6, PHD finger containing is a protein that in humans is encoded by the MLLT6 gene. [5]


References

  1. ^ a b c ENSG00000275851 GRCh38: Ensembl release 89: ENSG00000275023, ENSG00000275851 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038437 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MLLT6, PHD finger containing". Retrieved 2018-10-19.

Further reading

  • Pan JL, Xue YQ, Jiang HY, He J, Wang W, Wu YF (August 2005). "[Application of reverse transcription-multiplex nested PCR to detect MLL rearrangement in AML-M4/M5]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi (in Chinese). 22 (4): 444–6. PMID 16086288.


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