JWH-372

JWH-372 (naphthalen-1-yl-[1-pentyl-5-[2-(trifluoromethyl)phenyl]pyrrol-3-yl]methanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as a potent and selective agonist of the CB₂ receptor. JWH-372 binds approximately 9 times stronger to the CB₂ receptor (K_i = 8.2 ± 0.2nM) than the CB₁ receptor (K_i = 77 ± 2nM). The selectivity of JWH-372 for the CB₂ receptor is likely due to the electron-withdrawing character of the trifluoromethyl group rather than steric effects, as the o-methyl compound JWH-370 was only mildly selective for the CB₂ receptor (CB₁ K_i = 5.6 ± 0.4nM, CB₂ K_i = 4.0 ± 0.5nM). ^[1]

Legality

In the United States JWH-372 is not federally scheduled, although some states have passed legislation banning the sale, possession, and manufacture of JWH-372.^[2][3][4][5]

In Canada, JWH-372 and other naphthoylpyrrole-based cannabinoids are Schedule II controlled substances under the Controlled Drugs and Substances Act.^{[citation needed]}

In the United Kingdom, JWH-372 and other naphthoylpyrrole-based cannabinoids are considered Class B drugs under the Misuse of Drugs Act 1971.^{[citation needed]}

See also

• List of JWH cannabinoids
• Synthetic cannabinoid

References

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