Homochlorcyclizine

Chemical compound
  • none
Legal statusLegal status
  • In general: ℞ (Prescription only)
Identifiers
  • 1-[(4-chlorophenyl)-phenylmethyl]-4-methyl-1,4-diazepane
CAS Number
  • 848-53-3
PubChem CID
  • 3627
ChemSpider
  • 3501
UNII
  • N5MVC31W2N
KEGG
  • D08041
ChEMBL
  • ChEMBL151447
CompTox Dashboard (EPA)
  • DTXSID9045635 Edit this at Wikidata
ECHA InfoCard100.011.545 Edit this at WikidataChemical and physical dataFormulaC19H23ClN2Molar mass314.86 g·mol−13D model (JSmol)
  • Interactive image
  • CN1CCCN(CC1)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl

Homochlorcyclizine (INN) is an antihistamine of the diphenylmethylpiperazine group which has been marketed in Japan since 1965.[1] It is used in the treatment of allergies and other conditions. It also has some anticholinergic, antidopaminergic, and antiserotonergic properties.[2][3]

See also

References

  1. ^ "Homoclomin Tablets 10 mg" (PDF). Eisai Co. December 2007. Retrieved 2008-07-29. [dead link]
  2. ^ Haraguchi K, Ito K, Kotaki H, Sawada Y, Iga T (June 1997). "Prediction of drug-induced catalepsy based on dopamine D1, D2, and muscarinic acetylcholine receptor occupancies". Drug Metabolism and Disposition. 25 (6): 675–84. PMID 9193868.
  3. ^ KIMURA ET, YOUNG PR, RICHARDS RK (1960). "Pharmacologic properties of N-p-chloro-benzhydryl-N'-methyl homopiperazine dihydrochloride (homochlorcyclizine; SA-97), a serotonin antagonist". Journal of Allergy. 31: 237–47. doi:10.1016/0021-8707(60)90052-6. PMID 14409112.
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Benzimidazoles (*)DiarylmethanesEthylenediaminesTricyclicsOthers
For topical use
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mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(and prodrugs)
See also
Receptor/signaling modulators
Nicotinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators
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nAChRsTooltip Nicotinic acetylcholine receptors
Agonists
(and PAMsTooltip positive allosteric modulators)
Antagonists
(and NAMsTooltip negative allosteric modulators)
Precursors
(and prodrugs)
See also
Receptor/signaling modulators
Muscarinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators
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H1
Agonists
Antagonists
  • Unknown/unsorted: Azanator
  • Belarizine
  • Elbanizine
  • Flotrenizine
  • GSK1004723
  • Napactadine
  • Tagorizine
  • Trelnarizine
  • Trenizine
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists
See also
Receptor/signaling modulators
Monoamine metabolism modulators
Monoamine reuptake inhibitors
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5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT3–7
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7
  • See also: Receptor/signaling modulators
  • Adrenergics
  • Dopaminergics
  • Melatonergics
  • Monoamine reuptake inhibitors and releasing agents
  • Monoamine metabolism modulators
  • Monoamine neurotoxins